Chemical Properties:
Package: Bottle, Aluminium foil bag, 25kg/Cardboard Drum, or according to customer's requirement. Storage Condition: Moisture sensitive. Store in sealed containers at cool and dry (2~8℃) warehouse away from incompatible substances. Protect from light and moisture. Store away from oxidizing agent. Shipping: Deliver to worldwide by FedEx / DHL Express. Provide fast and reliable delivery. Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Bis(2-oxo-3-oxazolidinyl)phosphinic Chloride (BOP-Cl) (CAS: 68641-49-6) with high quality. Ruifu Chemical supplys a series of protecting reagents and coupling reagents. Ruifu can provide worldwide delivery, competitive price, small and bulk quantities available. Purchase BOP-Cl, Please contact: alvin@ruifuchem.comDescription:
Package/Storage/Shipping:
| Chemical Name | Bis(2-oxo-3-oxazolidinyl)phosphinic Chloride |
| Synonyms | BOP-Cl; N,N-Bis(2-oxo-3-oxazolidinyl)phosphinic Chloride; Bis(2-oxo-3-oxazolidinyl)phosphorodiamidic Chloride; Phosphoric Acid bis(2-oxooxazolidide) Chloride |
| Stock Status | In Stock, Mass Production |
| CAS Number | 68641-49-6 |
| Molecular Formula | C6H8ClN2O5P |
| Molecular Weight | 254.56 g/mol |
| Melting Point | 190.0~200.0℃ |
| Density | 1.71±0.10 g/cm3 |
| Sensitive | Moisture Sensitive |
| Solubility in N,N-DMF | Almost Transparency |
| Solubility | Soluble in Dimethylformamide |
| Storage Temp. | Cool & Dry Place (2~8℃) |
| COA & MSDS | Available |
| Category | Coupling Reagents |
| Brand | Ruifu Chemical |
Advantages:
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals. Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc. Advantages? Superior quality, affordable price, professional services and technical support, fast delivery. Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc. Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers. Factory Audit? Factory audit welcome. Please make an appointment in advance. MOQ? No MOQ. Small order is acceptable. Delivery Time? If within stock, three days delivery guaranteed. Transportation? By Express (FedEx, DHL), by Air, by Sea. Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided. Custom Synthesis? Can provide custom synthesis services to best fit your research needs. Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.FAQ:
Stable Supply: Maintain reasonable stock
Professional Service: One stop purchasing service
Technical Support: Technology solution available
Custom Synthesis Service: Ranged from grams to kilos
Fast Delivery: If within stock, three days delivery guaranteed
High Quality: Established a complete quality assurance system
Sufficient Capacity: Sufficient facilities and technicians
OEM Package: Custom package and label available
Specifications:
| Items | Inspection Standards | Results |
| Appearance | White to Off-White Crystalline Powder | Complies |
| Melting Point | 190.0~200.0℃ | 196.0~198.0℃ |
| Loss on Drying | <0.50% | 0.12% |
| Purity / Analysis Method | >99.0% (Argentmetric Titration) | 99.5% |
| Infrared Spectrum | Conforms to Structure | Complies |
| Proton NMR Spectrum | Conforms to Structure | Complies |
| Conclusion | The product has been tested & complies with the given specifications | |
68641-49-6 - Risk and Safety:
Application:
Hazard Symbols C - Corrosive Risk Codes 34 - Causes burns Safety Description S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S27 - Take off immediately all contaminated clothing. UN IDs UN 3261 8/PG 2 WGK Germany 3 RTECS SZ5871000 FLUKA BRAND F CODES 10-21 Hazard Class 8 Packing Group IIBis(2-oxo-3-oxazolidinyl)phosphinic Chloride (BOP-Cl) (CAS: 68641-49-6), reagents for carboxyl activation and peptide coupling. BOP-Cl was used in the preparation of hexadepsipeptide. Also used as reagent is used for activating the carboxylic group, synthesis of amides, esters and peptides. BOP-Cl is a highly effective reagent for the acylation of N-methyl amino acids. It provides good yields with low epimerization. BOP-Cl is also an efficient reagent for coupling protected amino monothioacids to iminoamino acid residues to form thiopeptide bonds. BOP-Cl is a phosphoric acid derivative used as a coupling reagent for amide and ester formation. BOP-Cl is effective in the acylation of N-methylated amino acids and in the introduction of thiopeptide bonds on imino acids. BOP-Cl requires mild conditions, gives good yields and suppresses epimerisation. BOP-Cl and other phosphinic acids activate the carboxylic acid by forming a carboxylic-phosphinic mixed anhydride, in which stereochemistry is conveniently retained. BOP-Cl gives good performances in the acylation of N-methylated amino acids due to intramolecular base catalysis.